Seattle biotech BrainChild Bio raises $116M to advance CAR T therapy for childhood brain cancer

What happens here matters everywhere. by John Cook on Sep 10, 2026 at 9:34 am September 10, 2026 at 9:35 am Seattle biotech startup BrainChild Bio has raised $116 million to advance an experimental CAR T cell therapy for one of the deadliest forms of childhood brain cancer.

The Series A financing will primarily fund a pivotal Phase 2 clinical trial of an investigational therapy being developed for diffuse intrinsic pontine glioma, or DIPG. The rare brainstem tumor primarily affects children ages 5 to 10 and has few treatment options.

The financing was led by an undisclosed private family fund and foundation, with participation from BrainChild Bio’s initial investor, Seattle Children’s, and new investor WRF Capital. BrainChild Bio is building on CAR T cell technology developed at Seattle Children’s and licensed exclusively to the company in 2023.

The approach involves genetically engineering a patient’s own T cells to recognize and attack cancer cells. The company says its new therapy has now entered its ILLUMINATE Phase 2 study, designed as a registration-stage trial that could eventually support an application to the U. S. Food and Drug Administration.

DIPG presents a particularly difficult challenge for cancer researchers because the tumors grow in the brainstem, an area critical to basic functions, and the blood-brain barrier can limit the ability of treatments to reach the tumor.

BrainChild Bio’s approach delivers the CAR T cells directly into cerebrospinal fluid through an implanted catheter, allowing the cells to reach the tumor locally and potentially be administered repeatedly. About 300 children in the U. S.

are diagnosed with DIPG each year, a devastating brain tumor with no cure and few treatment options. Radiation is the current standard of care, but children diagnosed with DIPG have a median overall survival of only about 11 months.

BrainChild Bio also plans to use proceeds from the new financing to advance a CAR T therapy designed to target three different cancer markers, toward initial clinical testing in glioblastoma.

The company was founded by Michael Jensen , who previously helped develop the underlying work at Seattle Children’s and was a co-founder of Umoja Biopharma and Juno Therapeutics. The CEO is Steven Brugger , who most recently served as founder and CEO of Affinivax, a biotech company which was acquired by GSK for $3.

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